Abstract Background Aberrant inflammatory responses drive the initiation and progression of various diseases. and hyperactivation of NLRP3 inflammasome is a key pathogenetic mechanism. Pharmacological inhibitors of NLRP3 represent a potential therapy for treating these diseases but are not yet clinically available. The natural product butein has excellent anti-inflammatory activity. https://www.roneverhart.com/Western-Digital-Re-WD6001FSYZ-6TB-7-2K-RPM-SATA-6Gb-s-128MB-3-5-Hard-Drive/