Abstract Background Acupuncture is widely used for knee osteoarthritis (KOA). despite contradictory evidence. This study is designed to determine the efficacy of electro-acupuncture and manual acupuncture versus sham acupuncture for KOA. Methods/design This is a multi-center three-arm randomized controlled trial. https://allfixelectricales.shop/product-category/powermos-transistor/